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Acetylcholine is a neurotransmitter found throughout the peripheral and central nervous systems and is well known for its importance in muscle contraction, attention, learning, memory, and stress.* Acetylcholine released by the vagus nerve is essential to immune health due to its ability to downregulate cytokine expression in the spleen, liver, and gastrointestinal tract.* Key ingredients Acetyl-L-carnitine: Derivative of L-carnitine shown to increase plasma and brain levels of L-carnitine. L-carnitine facilitates energy production in mitochondria and provides antioxidant protection through its ability to scavenge reactive oxygen species and metal ions.* Provides an acetyl group required for acetylcholine synthesis.* Choline bitartrate: Choline donor and precursor to acetylcholine. Choline is an essential nutrient important for cell health, methylation and lipid metabolism.* AlphaSize® (Alpha-glycerylphosphorylcholine): Patented choline donor and precursor to acetylcholine. Huperzia serrata aerial parts (standardized to 1% to huperzine A): Potent and selective inhibitor of acetylcholinesterase (AChE), an enzyme that breaks down acetylcholine in the synapse.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Key ingredients N-acetyl-L-cysteine: Precursor to L-cysteine, which is required for the synthesis of glutathione, an endogenous antioxidant important for mediating oxidative stress (1,2).* L-cysteine modulates glutamate activity through activation of cystine/glutamate antiporters (3). L-theanine: Amino acid that acts as a glutamate receptor antagonist (4).* Glutamatergic signaling underlies mechanisms related to anxiousness and stress (5). In a double-blind, placebo-controlled study, L-theanine was shown to significantly reduce stress (6).* Alpha-lipoic acid: Antioxidant that is able to regenerate endogenous antioxidants and scavenge metal ions and free radicals (7).* Evidence suggests the insulin-signaling pathway is sensitive to redox status (7). Alpha-lipoic acid can influence the redox status in cells important for the translocation of glucose transporters and increasing glucose uptake (7).* Coenzyme Q10: Compound found in nearly every human cell that is essential for mitochondrial function and antioxidant protection (8).* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Key ingredients Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (1-3).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (4-6). L-theanine: Amino acid that acts as a glutamate receptor antagonist (7)*. In a randomized, double-blind, placebo-controlled study, L-theanine was shown to significantly reduce stress (8)*. 5-HTP (from Griffonia simplicifolia seed extract): 5-hydroxytryptophan (5-HTP) crosses the blood-brain barrier and is a precursor to serotonin and melatonin (9).* Serotonin is important for regulating mood and sleep-wake function (10). In a randomized, double-blind study, 5-HTP was shown to significantly improve mood (11).* Vitamins B and C: Active forms of vitamin B6, folate, B12, and C are important for serotonin synthesis (12-16).* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
